The Best Acne Treatment

Contrary to the marketing promises of “blemish banishers” and “zit zappers,” immediate results are not the trademark of acne treatments — a frustrating truth to anyone suffering through a breakout. And while pimples are personal (your stress-induced spots will look and act differently than your best friend’s breakout), the best acne treatments will include a regimen of products to hit all of acne’s root causes. We tested 43 kits to find the most well-rounded breakout-fighting solutions on the market.

The 3 Best Acne Treatments

Best for Skin Protection
Paula’s Choice Clear Regular Strength System
Paula's Choice
This twice-daily kit achieves a solid balance between fighting acne while also preserving and protecting your skin.
Pros
Simplicity
Cleansing properties
Active ingredients
Cons
No SPF in the kit

Why we chose it

Simplicity

If you’re used to seeing advertisements for acne treatments using five or six different products to clear up blemishes, you might be surprised that a simple three-step kit is our top pick. In fact, we favored Paula’s Choice for its simplicity. This twice-daily, three-step kit — which includes a cleanser, an anti-redness exfoliant, and a leave-on treatment — is concise without cutting corners.

Active ingredients

The Anti-Redness Exfoliating Solution is mostly water, but its 2 percent salicylic acid is enough to eat through oil and remove the dead skin cells clogging your pores — and it boasts a higher concentration than nearly every other kit we looked at. Sodium hyaluronate, the super-moisturizing humectant we fell in love with in our review on the Best Face Moisturizer, also caught our eye sitting smack dab in the middle of the ingredients list.

The Daily Skin Clearing Treatment is an all-over 2.5 percent benzoyl peroxide cream that also touts calming bisabolol and allantoin to alleviate the dryness and irritation that can crop up mid-treatment. Anyone frustrated with oil-slick skin will also love this part of the regimen — it creates a satin mattifying effect, instantly transforming shininess into a glow.

Mild cleanser

The Pore Normalizing Cleanser is designed just to cleanse, not treat, which is a good thing: The Nurse Practitioner study emphasizes the importance of washing with mild cleansers in conjunction with topical acne medications to combat or avoid excessive skin irritation. This one is water-based and fragrance-free, and uses sodium laureth sulfate (as opposed to its harsh cousin sodium lauryl sulfate) to eliminate any chance for irritation.

Points to consider

No SPF in the kit

The three-piece set doesn’t come with a sun protection treatment, but Paula’s Choice has one in the line, the Clear Ultra-Light Daily Fluid SPF 30+. “Sun protection is really important, especially with acneic skin,” says Townsend. “In many cases, stronger acne products can make the skin photosensitive to the sun.” This isn’t your normal gloppy white sunscreen. Its fluid formula slips over tender skin, doesn’t need a ton of rubbing in, and also leaves a mattifying finish.

Best High-Dose Treatment
Proactiv+ 3-Step System
Proactiv
Proactiv offers a number of kits, but this is the one to get — the combo of benzoyl peroxide and salicylic acid provides a solid one-two punch.
Pros
High doses of benzoyl peroxide
Ease of application
Cons
Exfoliant
Small bottles

Why we chose it

High doses of benzoyl peroxide

All of Proactiv’s regimens are heavy on the benzoyl peroxide, and the Proactiv+ 3-Step kit is no exception. It comes with a 2.5 percent benzoyl peroxide wash, a 2.5 percent benzoyl peroxide gel, and a 0.5 percent salicylic acid moisturizer. We also appreciated the balance of bacteria-fighting and moisturizing ingredients in the set.

Ease of application

The Pore Targeting Treatment gel and Complexion Perfecting Hydrator moisturizer slip on nicely, with the former powered by skin-loving glycerin and the latter by a whole slew of delicious ingredients, like licorice root extract, sodium hyaluronate, bisabolol, and allantoin. The three-step solution is easy to use and makes cleansing the face a quick, efficient process.

Points to consider

Exfoliant

We are iffy on the Skin Smoothing Exfoliator face wash, and not just because the microbead granules can be harsh on active breakouts. “Acne products that are washes will tend not to work as well as leave-on or rub-in products,” explains Dr. Green. “Think about it. How well can a product work when rinsed off a few seconds after you put it on?”

Small bottles

The other downside to Proactiv+ is that the bottles are small — like, half the size of Paula’s Choice small. Combine that with its recommended two or three-times daily application, and you’re going to be going through a lot of kits, which ultimately means spending more money on your treatment. If Proactiv is the only thing that works for you, it may very well be worth the investment, but we recommend starting with Paula’s Choice to see if you can get the same results at a cheaper price.

Best for Natural Ingredients
Dermalogica Clean Start Breakout Clearing Kit
Dermalogica
This five-piece set has everything we want in an acne kit, but only the teeny travel-size option is sold as a set.
Pros
Gentle, effective ingredients
SPF included
Cons
Not cost-effective (travel-size only)

Why we chose it

Gentle, effective ingredients

We loved the mix of salicylic acid and benzoyl peroxide, plus all-natural heavy hitters, like tea tree oil and witch hazel. Dermalogica prides itself in creating products without using artificial fragrances or colors; plus, the Clear Start kit is vegan-, gluten-, and cruelty-free.

SPF included

For those with acne-prone skin, it can be tough finding a sunscreen that doesn’t clog pores and meshes well with your skincare regimen. Oily sunscreens often lead to breakouts. In addition to the wash, toner, moisturizer and treatments, the Clear Start kit includes an acne-safe (read: oil-free) sunscreen in its lineup — perfect for those wanting the best of both worlds in avoiding all types of red faces.

Points to consider

Not cost-effective (travel-size only)

Dermalogica sells its full-size Clear Start products a la carte (all at around $20 each), so this line is definitely not made for the thrifty. There are more options outside the kit, but if these formulas are the only ones that work for you, you might be burning through the products and the contents of your wallet pretty quickly.

How to Find the Right Acne Treatment for You

Know that less might be more

“You unfortunately cannot determine the strength of a product strictly by the percentage of its active ingredients because how well a product works depends on how well its inactive ingredients help it penetrate the skin,” explains Dr. Green. “In other words, a 2 percent benzoyl peroxide may be more effective than another brand’s 5 percent benzoyl peroxide because there are other ingredients helping out.”

When we asked what those types of other ingredients are, Dr. Green said there were no clear answers there either — skin is too subjective. “I think the best answer is to use one that feels good and rubs into your skin well without over-drying it,” he says. The more comfortable it is to apply, the more likely you are to keep up the regimen.

Get into a routine

Every expert we spoke with said the most critical part of combating acne is combating it every day. “The only way to make any medication work is to use it on a daily basis,” says Dr. Green. Fitz Patrick emphasizes that it really comes down to what you can maintain for the long term: “Kits are great because they take out all the guesswork -- you just follow the instructions. But if four steps is going to be too many for you to keep up week after week, you’ll be better off finding one that has fewer treatments.”

Any acne treatment is a weeks-long experiment that you’re conducting with your skin. Acne is slow to heal, and in some cases, it can get worse before it gets better (nearly every benzoyl peroxide product we looked at emphasized the likeliness of irritating acne further, and starting off with a lighter application). April W. Armstrong, a doctor at the University of California Davis Health System, recommends waiting at least one month before you deem a product ineffective.

In most cases, acne products need to be used for at least 30 days before you can begin to ascertain its efficacy. Some skin and acne types may see noticeable results in a few days and end up totally clear in just a few weeks. Others may take several weeks to see the slightest change, or need to have their regimen adjusted as their skin adapts. Treating acne can often be a months-long process.

Treat your skin with care

Your pimples need TLC, too. The study on acne vulgaris found that, in an attempt to dry out acne lesions, patients often use too many products or apply excessive amounts to problem areas, resulting in further irritation and over drying of the skin. Vigorous scrubbing and using harsh exfoliants can make acne worse by rupturing whiteheads and blackheads, turning them into painful red ones. And remember: no matter how satisfying it is, picking and popping your zits will also increase inflammation and opportunity for infection.

Choose your makeup carefully

Acne treatments can be made moot if you pile on pore-clogging cosmetics. Look for labels that state non-comedogenic — or get started with our review on the Best Foundation.

Talk to a skincare pro

If your acne is severe, painful, or refusing to get lost, you may just be beyond what an over-the-counter treatment can do. Not only can a professional set you up with the really powerful stuff, but also Fitz Patrick explains that “working closely with an aesthetician or dermatologist means you can keep tweaking a routine to make it work best for you.”

Acne Treatment FAQ

What is acne?

Acne vulgaris is the catch-all term for everything from angry red lesions to tiny white bumps, which are the results of hair follicles and their sebaceous glands becoming blocked and inflamed So our first plan was to look at it all — spot treatments, washes, scrubs and creams — until we learned that when it comes to over-the-counter treatments, there is no single cure.

What causes acne?

Genetics play a big part in who gets acne and how severely, but each blemish can be blamed on some combination of sebum production, a bacteria called Propionibacterium acnes (P. acnes), plugged follicles, and inflammation. Finding a good treatment is really about finding the right combination of ingredients to troubleshoot each of those issues. Some factors that might worsen acne include hormones, certain medications, diet and stress.

What are the best products to get rid of acne?

Because “acne” encompasses everything from small whiteheads to severe cystic acne, keep in mind that what may work best for one person may not work best for another. If your acne is severe enough that it’s affecting the quality of your daily life, we recommend talking to a doctor or a dermatologist before you begin any treatment.

Keep in mind that even if some products market themselves toward severe acne breakouts, all the kits we looked at are definitely designed for mild to moderate acne. Not sure if you fit on that scale? You’re not alone! When you’re in the middle of a breakout, all acne seems severe, so it can be difficult to self-diagnose your symptoms. We talked to dermatologists and cosmetic chemists to better understand the differences between the various types of acne (see below).

One word of caution, though: Dr. Green warns that even moderate acne can be beyond what an over-the-counter treatment can handle and recommends seeing a specialist. Our advice: track your progress while using any over-the-counter treatments, and consider consulting a doctor if you skin continues to worsen or not improve after one month.

What are the different acne types?

Type Description
Hormonal Acne - Inflammation (most commonly along the chin and jawline), appears cyclically with menstrual cycles for women
- Can be treated with antibiotics or birth control
Subclinical acne - A small number of blackheads and whiteheads that are barely visible
- The first signs of a blemish
Comedonal acne - Blackheads and whiteheads that might be a little red
- Visible blemishes
Mild acne - Several inflamed pimples
- Fewer than 20 whiteheads or blackheads
- Fewer than 15 inflamed pimples
- Fewer than 30 pimples that aren’t all inflamed
Moderate acne - Many inflamed pimples and pustules
- 20-100 whiteheads or blackheads
- 15-50 inflamed pimples
- 20-125 pimples that aren’t all inflamed
Severe nodular acne - Inflamed pimples and pustules plus a few deep nodules (those solid suckers you can feel under your skin)
- More than 5 cysts (hard knots of skin)
Severe cystic acne - Many nodular cystic pimples with signs of scarring

Are there any side-effects to breakout creams?

The side effects depend on the type of treatment you use. Generally, for topical, over-the-counter creams, you can watch out for stinging, redness, irritation and peeling — these side effects usually don’t go any deeper than the skin. Others, like oral antibiotics or hormonal medications, could come with new sets of complications, so we suggest talking to your doctor before pursuing the treatment.

Are spot treatments effective?

We suggest avoiding spot treatments. “Benzoyl peroxide, when placed on red spots, can actually cause more irritation and inflammation to the area. It’s best used to prevent red bumps and pustules, and applied all over the area you want to treat,” said Townsend, who was also quick to naysay a spot-treat-only approach: “Acne affects all of the pores. If someone is going to spot treat against my advice, I still suggest they spot treat one day and treat the whole face the next.”

The Best Acne Treatments: Summed Up

Paula’s Choice Clear Regular Strength System
Proactiv+ 3-Step System
Dermalogica Clean Start Breakout Clearing Kit
Best for Skin Protection
Best High-Dose Treatment
Best for Natural Ingredients
Price
$58
$80
$94
Active Ingredients
Salicylic acid, benzoyl peroxide
Salicylic acid, benzoyl peroxide, sulfur
Salicylic acid, benzoyl peroxide
SPF Included

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