The Best Allergy Medicine
We talked to a trio of allergists and they all agreed: a spritz of corticosteroid up the nose is the best way to beat seasonal allergies — but oral antihistamines and eye drops make great backups. We scoured the research and analyzed the 37 most available pills, sprays, liquids, and drops at mainstream pharmacies to find the best symptom-relieving (and least zombifying) defense during allergy season.
A gentle steroid spray that treats inflammation without affecting your adrenal system. The water-based formula is free of scent and alcohol, making it a good choice for sensitive noses.
Allegra Allergy 24 Hour
A non-drowsy oral antihistamine developed to target allergies with minimal side effects, just a little less effective than a nasal spray. Its 24-hour formula is available as a tablet or gel-cap.
A liquid formula with a lower dosage that’s safe for children under 12. Its non-drowsy 12-hour formula comes in two flavors: berry and orange cream.
- January 18, 2018 - We've updated this page to streamline our top picks and bring it in line with our current template. We’ll be doing a complete overhaul of this review in the coming months to delve deeper into ingredients and the difference between delivery methods.
The Best Allergy Medicine
Fighting allergies can feel like a war on pollen. And kittens. Yet the real enemy lies within: For those of us with allergies, our immune systems overreact to pollen, animal dander, mold, and dust. It flags these as invaders and goes on the attack, releasing histamine, which in turn triggers the itchy eyes, runny nose, and congestion we all associate with the start of spring. When it comes to allergy medicine you have two main options: nasal spray or oral antihistamine. They both essentially do the same thing, but one you swallow, and one you spray up your nose.
Our top pick is a nasal spray because they’re simply more effective as a standalone defense. Nasacort Allergy 24 Hour’s active ingredient, triamcinolone, treats inflammation locally instead of disrupting your entire adrenal system, like some competitors. Its 24-hour formula is alcohol- and scent-free, non-drowsying, and only requires once-daily application (when needed) at $0.10 per dose.
If your poor embattled nose just can’t handle a spray, Allegra Allergy 24 Hour pills will work well too. The active ingredient, fexofenadine, is known for being non-sedating, so there’s no concern about drowsiness here. It’s also a 24-hour option and conveniently comes in both tablet and gel cap forms. It’s more than three times the cost of Nasacort, at $0.35 per dose, but it’s ideal for a sensitive nose and also only needs a single dose per day.
The adult doses of active ingredients are not recommended for children under 12, so Children's Allegra Allergy 12 Hour liquid is our top pick for kids with allergy symptoms. It has the same active ingredient as our Runner Up, simply in a smaller amount (30 mg vs. 180 mg) — meaning it won’t make your young one too drowsy for school. Its 12-hour liquid formula works out at $0.45 per dose, and comes in Berry and Orange Cream flavors.
How We Found the Best Allergy Medicine
We started with a list of 37 allergy medications sold at mainstream pharmacies (Walgreens, Target, Duane Reade, etc.), then talked to immunologists and read academic scientific journals to find which ones work best. Everything we looked at is over-the-counter — no prescription necessary. (According to allergist Dr. Marie Cavuoto Petrizzo, prescription options are generally considered a last resort, “after a patient has exhausted the OTC stuff and found no relief.”)
First, we cut any “first generation” antihistamines.
The earlier the medication was developed, the more side effects, such as sedation, memory impairment, and dry mouth.
These drugs started coming out in the 1940s, before clinical studies of new medications became standard. First-gen antihistamines affect histamine receptors in the brain, not just the body, meaning significant drowsiness and other negative side effects. (You may have experienced the zombifying aftermath of Benadryl.) By comparison, second- and third-generation antihistamines, like Claritin and Zyrtec, which started hitting the market in the ‘80s, target the effects of histamine solely in the body, so you don’t get such a groggy feeling.
Decongestants? No thanks.
Pharmaceutical companies market decongestants as good for your allergy-related stuffy nose, but Dr. Marie Cavuoto Petrizzo, pediatric allergist-immunologist, says allergists rarely recommend them: “They’re not treating the allergy, but masking the symptoms and they can cause side effects.” Indeed, decongestants act as a vasoconstrictor, shrinking blood vessels to relieve pressure in the nose and enable the passage of air. However, warns Dr. Cavuoto Petrizzo, at the same time they can also increase blood pressure, which can be a problem as many patients don’t realize they already have high blood pressure. Oral decongestants may also not be safe for patients with glaucoma, heart conditions, diabetes, and thyroid disease. So adding a decongestant can be just plain dangerous. Talk to your doctor before using an allergy medicine if you have any of these conditions.
Decongestants can also cause sleeplessness, and Dr. Rebecca Vanlandingham notes that nasal spray versions can trigger “rebound congestion” if used for more than a couple of days. And if you’ve ever suffered from seasonal allergies, you know you’re probably in it for the long haul.
Afrin NoDrip Original
Afrin NoDrip Severe Congestion
Afrin NoDrip Sinus
Afrin Severe Congestion
Neo-Synephrine Extra Strength
Qlearquil 12 Hour Nasal Decongestant Moisturizing Spray
Sudafed 12 Hour
Sudafed 24 Hour
Sudafed PE Congestion
Visine-A Allergy Relief
We also eliminated anything containing acetaminophen.
Acetaminophen, the pain reliever found in Tylenol, is full of controversy: On one hand, the World Health Organization lists it as an essential medicine, meaning it satisfies priority health care needs without compromising safety. On the other, studies link long-term, high-dose usage to liver failure, kidney disease, gastrointestinal bleeding, and more nasty stuff.
According to Dr. Cavuoto Petrizzo, it’s added to some allergy medicines to help alleviate headaches and sinus pain that may accompany allergic congestion. But some of the allergy meds we looked at contained 650 mg of acetaminophen per dose (the same as two Tylenol) and a dosage frequency of every four hours, for a total of up to 3,900 mg per day. This gets you pretty close to the recommended maximum of 4,000 mg a day, which may be an excess of pain relief, especially if you’ve just got an itchy throat and don’t need it. If you find you need to take your allergy medicine all season, you may be putting yourself at unnecessary risk of serious health problems. So we cut all products that included acetaminophen, as you can always take it, or other more heavy-duty pain relief, separately as needed.
Physicians Care Allergy
Qlearquil Sinus & Congestion Relief
Tylenol Sinus & Congestion Daytime Caplets
Tylenol Sinus Severe Daytime Caplets
This left us with 13 corticosteroid nasal sprays, antihistamine pills, and eye drops.
While nasal corticosteroids are widely considered the best standalone defense against mild to severe allergies, it’s important to note that different medicines have been formulated to treat different symptoms, and you can combine medicines for the best results. “In real life, many people take both nasal corticosteroids and antihistamines,” says Dr. Vanlandingham. “It really depends on what symptoms are bothering you the most.”
Likewise, antihistamine pills and eye drops can work beautifully in concert. “On those days during the really high-pollen season in April and May, pollen can actually blow into your eyes and cause an allergic reaction there,” explains Dr. Cavuoto Petrizzo. “In these instances, eye drops are going to provide the most immediate relief for itchy eyes, while the oral antihistamine works in the background, blocking histamine throughout the body.” Thus, we looked for the best of each type.
Our Picks for the Best Allergy Medicine
We crowned Nasacort king of the steroid sprays because its active ingredient, triamcinolone, effectively treats inflammation in the nose without affecting your adrenal system and the release of hormones throughout your body, unlike competitors like Flonase. In addition, Nasacort uses a water-based formula, free of alcohol and scent; according to Dr. Cavuoto Petrizzo, this makes it less likely to cause irritation in sensitive noses. At $13 for 120 doses (1 spray per day - $0.10/dose), Nasacort is also the best value of the steroid sprays.
Allegra’s third-generation antihistamine, fexofenadine, is one of a class of medicines developed with the goal of improving clinical efficacy and minimizing side effects. Indeed, in a 2011 study published in the New England Journal of Medicine and the Journal of Allergy and Clinical Immunology, researchers note that fexofenadine is the most consistently nonsedating of the later antihistamines — it really won’t make you drowsy. They recommend it specifically for “airline pilots and others in safety-critical occupations,” but safety and alertness are important for pretty much anyone in our book, so we’ve given Allegra top honors among the antihistamines. Allegra’s 24-hour formula is available in both a tablet and gel cap, making it a versatile option too. At $25 for 70 doses (1 tablet per day - $0.35/dose), Allegra is more expensive than our top pick, but a good choice if your nose is too sensitive for a spray.
Best for Children
Children’s Allegra relies on fexofenadine, the same active ingredient found in adult Allegra. That means no risk of drowsiness. Plus there’s ample research that it’s effective against seasonal allergies — and safe even for kids. It can be given to children as young as 2 and comes in a liquid 12-hour dose. Adults can also take it, but it has less fexofenadine than you’d probably want: 30 mg versus the 180 mg found in adult Allegra Allergy. If your child balks at anything remotely resembling cough syrup, you can also try Allegra’s meltable tablets. These contain the same active ingredient and dosage, though they’re not recommended for children younger than 6.
Others to consider
If you’re looking for eye drops...
At $10 for 0.34 fluid ounce, Alaway stands out as the most cost-effective eye drop for allergies. But be aware that all allergy eye drops — including our top pick — come with a caveat: The preservative BAK (benzalkonium chloride) helps your eyes absorb active ingredients like ketotifen, but Dr. Anna George, allergist and immunologist at The Woodlands Allergy told us, “There is a large body of evidence that BAK has toxic effects on the ocular surface that is time- and dose-dependent. Because of this, I do not recommend daily, year-round use of allergy eye drops.” That doesn’t mean you need to steer clear of them altogether. “If they’re used sporadically through the season or with random allergy encounters (like cat dander) they’re likely to be safe for most people,” Dr. George told us. In other words, don’t use them every day. And if you need to, talk to your doctor about prescription options. According to Dr. Laura Periman, ophthalmologist and leading dry eye expert, suggested: “Prescription-grade antihistamine drops are significantly more effective than OTCs and have much lower BAK levels with less need for repeat dosing.”
If you’re pregnant...
Unlike most other steroid sprays, Rhinocort's active ingredient, bubesonide, means it can safely be used during any stage of a pregnancy. Rhinocort’s active ingredient, budesonide, is the only over-the-counter steroid spray that qualifies as category B for pregnancy — in other words, research shows that using Rhinocort in any trimester does not increase the risk of birth defects. All other steroid sprays get classified as category C and should only be used if the potential benefits to the mother outweigh the potential risks to the fetus (although we definitely recommend checking with your OB-GYN before taking any medicines, category B or otherwise). Like Nasacort, Rhinocort offers seasonal allergy relief without scent or alcohol, making it a good choice for moms-to-be with sensitive noses too.
If you don’t mind some drowsiness…
Studies show that cetirizine, the active drug in Zyrtec, may act faster than fexofenadine by anywhere from 20 minutes to two hours. However, Zyrtec is also associated with a higher incidence of drowsiness. Dr. Vanlandingham noted that some allergy sufferers choose to take 24-hour Zyrtec at night when drowsiness won’t impact them. If you do go for Zyrtec, you can choose between regular tablets, liquid gels, and quick-dissolve tabs. Zyrtec kicks in 20 minutes to 2 hours faster than Allegra. But its speed doesn’t come for free: This option can make some people drowsy and only lasts 12 hours.
Did You Know?
Allergy meds all work differently — and often better together.
Most experts tout corticosteroid nasal sprays, which work by reducing inflammation in the nose, as the best first-line defense for seasonal allergies. “When compared ‘head to head’ with standard dosed antihistamines, they show more benefit for people based on subjective reporting of symptoms,” says Dr. Lichtenberger, citing a 2001 study from the University of Chicago. The study gave fluticasone (FLONASE) to 44 participants and loratadine (Claritin) to another 44, all with similarly severe allergies. At the end of four weeks, the steroid nasal spray group reported less sneezing and congestion, as well as fewer runny noses than the antihistamine group.
For best results, start taking a nasal corticosteroid several weeks prior to the start of allergy season. “While their onset of action is 30 minutes, effectiveness may take several hours to days to occur. Their maximum effectiveness occurs after two to four weeks of use,” says Dr. Cavuoto Petrizzo.
Antihistamine pills have one clear advantage over nasal steroids: more rapid relief. Have you ever walked into a house with cats and swelled right up? “Antihistamines take 30 to 60 minutes to take effect and thus can be used on an as-needed basis for quick relief,” says Dr. Cavuoto Petrizzo. That said, antihistamines don’t treat congestion; corticosteroid sprays do, so many doctors suggest combining them.
Chances are that the combo of a nasal steroid spray and an oral antihistamine (or even just one of them) will alleviate dry, itchy eyes too. However, if you’re still suffering — perhaps due to an especially high pollen count — eye drops will give immediate relief while the other medicines work in the background.
Generic drugs will save you money.
Across the board, the doctors we consulted agree that generic drugs work just as well as name brands — and cost much less. If you’re looking at a shelf full of generics and don’t know which to choose, try comparing labels. Match the percentage of the active ingredient of the name brand, and then filter out anything with acetaminophen and decongestants. As a final check, make sure the box isn’t labelled with any scary-sounding warnings like “not safe for long-term use.” If all else fails, flag a pharmacist for advice.
You don’t have to take allergy medicine for the rest of your life.
If shooting a spray up your nose or popping a pill every day just isn’t your style, you may want to ask your doctor about immunotherapy, which actually treats your allergies rather than simply suppressing the symptoms. If you don’t already know what you’re allergic to, your doctor may begin by conducting a skin or blood test. From there, they’ll start you on a course of shots, injecting the substance you’re allergic to into your bloodstream, be it oak pollen or animal dander.
Keep in mind this isn’t a short-term treatment. “It starts out very dilute and then every week the concentration of the pollen increases for six or seven months,” says Dr. Cavuoto Petrizzo. “At that point we continue the injections once a month for two years. As your body keeps seeing these constant levels of an allergen, it learns to ignore it and ‘forgets’ that it’s allergic to it.”
Dr. Cavuoto Petrizzo says treatment is typically about 80 percent effective, and while it costs more up front than OTC meds, over time patients can save as their allergies dissipate and they no longer need medication. Plus, most PPO plans will cover between 60 percent and 100 percent of subcutaneous immunotherapy (SCIT).
Air purifiers can help with indoor allergies.
If you suffer from seasonal allergies, you’ve probably had days where it’s tempting not to leave the house. But research from the EPA suggests that air quality indoors is often worse than what’s outside: “Air within homes and other buildings can be more seriously polluted than the outdoor air in even the largest and most industrialized cities.” An indoor air purifier can help manage your symptoms, but make sure to do your research before you buy. Some types of air purifiers can actually make your allergies worse — in particular, models that release ozone (a common allergen) or rely on negative ionic filters (which “clean” air by causing particulate matter to stick to furniture, walls, and every other exposed surface). Most experts instead recommend air purifiers that use HEPA filters, which are able to trap the dander and pollen that many people are sensitive to. For specific product suggestions, take a look at our review of Best Air Purifiers.